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We've seen this happen when security software blocks the user's ability to write to CDs/DVDs. Run gpedit.msc and go to Windows Settings>Security Settings>Local Policies>Security Options and make sure Devices: Restrict CD-ROM access to locally logged-on user only is set to disabled.

Also, too many entries for mounted devices in older computers can cause this problem. When all the entries cleared the drive should work again. To do this, go to start and type regedit in the search field. Make sure to back up your registry before making any changes. Here are instructions for backing up your registry.

http://windows.microsoft.com/en-GB/windows-vista/Back-up-the-registry

In the directory list on the left side, find the entry HKEY_LOCAL_MACHINE\SYSTEM\MountedDevices. Remove all entries except for default (it won't let you anyway).

You can also look at Device Manager when the Data Traveler is connected to see if the drive comes up with any yellow exclamation marks. Uninstalling the device with the exclamation mark and scanning for new hardware sometimes will work as well. You may want to try this even if you do not see any yellow exclamation marks for this device. You will need to run the uninstall as the Admin to be able to perform this while logged-in as a non-Admin.

Also check the setting for your security programs (Norton, Symantec, etc).

FAQ: KDT-121311-PRV-03
To resolve, you will need to update your Ironkey D300S (Serialized) secure USB drive for MacOS Catalina. To update, click on the link below to download the
IKD300S_Updater.exe and IKD300S Updater Instructions. Note: Please read the updater instructions in its entirety prior to running the update.
Updater: https://media.kingston.com/support/downloads/IKD300S_Updater.zip

For more information about the "App” not optimized or “App” needs update error message,
feel free to reference Apple’s support article. https://support.apple.com/en-us/HT208436

MacOS: Must update on Windows based system. IKD300S_Updater.exe not supported on MacOS. FAQ: KIK-D300S-CATA

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